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Literature summary extracted from

  • Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
    Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells (2006), Biol. Chem., 387, 807-811.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.B10 medicine tumor-associated overexpression of tissue kallikreins contributes to ovarian cancer progression. Possibily effects observed may be due to the activity of only some of the four kallikreins hK4, hK5, hK6, and hK7 under survey Homo sapiens
3.4.21.B12 medicine tumor-associated overexpression of tissue kallikreins contributes to ovarian cancer progression. OV-MZ-6 ovarian cancer cells simultaneously expressing K4-7 display similar proliferative capacity as the vector-transfected control cells, but show significantly increased invasive behavior. Simultaneous expression of K4-7 in OV-MZ-6 cells and inoculated into the peritoneum of nude mice, results in a remarkable 92% mean increase in tumor burden compared to control cell line Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B10 OV-MZ-6 ovarian cancer cells stably co-transfected with pRc/RSV-plasmid expressing hK4, hK5, hK6, and hK7. Overexpression in OV-MZ-6 ovarian cancer cells and in the peritoneum of nude mice, inoculated with OV-KLK4+5+6+7 cells Homo sapiens
3.4.21.B12 KLK4, 5, 6, and 7 full-length cDNA cloned into vector pRc/RSV. OV-MZ-6 ovarian cancer cells stably co-transfected with plasmids expressing K4-7. These OVKLK4+5+6+7 cells inoculated into the peritoneal cavity of nude mice Homo sapiens
3.4.21.B39 overexpression in OV-MZ-6 cancer cell line inoculated into the peritoneal cavity of nude mice promotes tumor growth in mice Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B10 Homo sapiens
-
-
-
3.4.21.B12 Homo sapiens
-
-
-
3.4.21.B39 Homo sapiens
-
-
-
3.4.21.117 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B10 ovary cancer cell
-
 Homo sapiens
-
3.4.21.B12 ovary cancer cell
-
 Homo sapiens
-
3.4.21.117 ovary cancer cell overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B10 hK6 expression from KLK6 gene Homo sapiens
3.4.21.B10 KLK6
-
 Homo sapiens
3.4.21.B12 KLK4
-
 Homo sapiens
3.4.21.B39 hK5
-
 Homo sapiens
3.4.21.B39 human tissue kallikrein 5
-
 Homo sapiens
3.4.21.B39 KLK5
-
 Homo sapiens
3.4.21.117 KLK7
-
 Homo sapiens